購(gòu)物車(chē)
幫助
021-54845833/15800441009
儲(chǔ) 存： 冷凍（-20℃）
反應(yīng)種屬： Human
標(biāo) 記 物： Unconjugate
技術(shù)規(guī)格
|
Background: |
HLA-DOB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DOA) and a beta chain (DOB), both anchored in the membrane. It is located in intracellular vesicles. DO suppresses peptide loading of MHC class II molecules by inhibiting HLA-DM. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. |
|
Applications: |
ELISA, IHC |
|
Name of antibody: |
HLA-DOB |
|
Immunogen: |
Synthetic peptide of human HLA-DOB |
|
Full name: |
major histocompatibility complex, class II, DO beta |
|
Synonyms: |
DOB; HLA_DOB |
|
SwissProt: |
P13765 |
|
ELISA Recommended dilution: |
5000-10000 |
|
IHC positive control: |
Human tonsil |
|
IHC Recommend dilution: |
40-200 |
