兔抗KCNH2 多克隆抗體

Background:

This gene encodes a voltage-activated potassium channel belonging to the eag family. It shares sequence similarity with the Drosophila ether-a-go-go (eag) gene. Mutations in this gene can cause long QT syndrome type 2 (LQT2). Transcript variants encoding distinct isoforms have been identified. Pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel. Channel properties are modulated by cAMP and subunit assembly. Mediates the rapidly activating component of the delayed rectifying potassium current in heart (IKr). Isoform 3 has no channel activity by itself, but modulates channel characteristics when associated with isoform 1.

Applications:

ELISA, WB

Name of antibody:

KCNH2

Immunogen:

Synthetic peptide of human KCNH2

Full name:

potassium voltage-gated channel, subfamily H (eag-related), member 2

Synonyms：

ERG1, HERG, LQT2, SQT1, HERG1, Kv11.1

SwissProt:

Q12809

ELISA Recommended dilution:

1000-5000

WB Predicted band size:

90 kDa

WB Positive control:

Mouse brain tissue

WB Recommended dilution:

500-2000