兔抗KDM4B多克隆抗體

Background:

JMJD2B (JmjC domain-containing histone demethylation protein 3A) is a 1,064 amino acid protein encoded by the human gene JMJD2B. JMJD2B belongs to the JMJD2B histone demethylase family and contains one JmjC domain, one JmjN domain, two PHD-type zinc fingers and two Tudor domains. The two Tudor domains recognize and bind methylated histones and have an interdigitated structure; the unusual fold is required for its ability to bind methylated histone tails. JMJD2B is a histone demethylase that specifically demethylates Lys 9 residues of Histone H3, thereby playing a role in histone code. It does not demethylate Histone H3 Lys 4, H3 Lys 27, H3 Lys 36 or H4 Lys 20, however, and is only able to demethylate trimethylated H3 Lys-9 and has weaker activity than JMJD2A, JMJD2C and JMJD2D. JMJD2B demethyl-ation of Lysine residues will generate formaldehyde and succinate. JMJD2B is a ubiquitously expressed nuclear protein.

Applications:

ELISA, IHC

Name of antibody:

KDM4B

Immunogen:

Synthetic peptide of human KDM4B

Full name:

lysine (K)-specific demethylase 4B

Synonyms：

JMJD2B; TDRD14B

SwissProt:

O94953

ELISA Recommended dilution:

2000-5000

IHC positive control:

Human ovarian cancer and Human cervical cancer

IHC Recommend dilution:

50-200