兔抗ACTN1/2/3/4多克隆抗體

Background:

Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, cytoskeletal, alpha actinin isoform and maps to the same site as the structurally similar erythroid beta spectrin gene. Three transcript variants encoding different isoforms have been found for this gene.

Applications:

WB

Name of antibody:

ACTN1/2/3/4

Immunogen:

Synthesized peptide derived from internal of human ACTN4.

Full name:

actinin, alpha 1/2/3/4

Synonyms：

BDPLT15/CMD1AA/FSGS; FSGS1; ACTININ-4

SwissProt:

P12814/P35609/Q08043/O43707

WB Predicted band size:

103/104/103/105 kDa

WB Positive control:

293 cells, Hela cells and A549 cells lysates

WB Recommended dilution:

500-3000