小鼠抗PRTN3單克隆抗體

Background:

Serine protease that degrades elastin, fibronectin, laminin, vitronectin, and collagen types I, III, and IV (in vitro) (PubMed:3198760, PubMed:2033050, PubMed:28240246). By cleaving and activating receptor F2RL1/PAR-2, enhances endothelial cell barrier function and thus vascular integrity during neutrophil transendothelial migration (PubMed:23202369). May play a role in neutrophil transendothelial migration, probably when associated with CD177 (PubMed:22266279).

Applications:

WB

Name of antibody:

PRTN3

Immunogen:

Fusion protein of human PRTN3

Full name:

proteinase 3

Synonyms:

MBN; MBT; NP4; P29; PR3; ACPA; AGP7; NP-4; PR-3; CANCA; C-ANCA

SwissProt:

P24158

WB Predicted band size:

28 KD

WB Positive control:

Human spleen tissue lysate

WB Recommended dilution:

200-1000