小鼠抗SSB單克隆抗體

Background:

The protein encoded by this gene is involved in diverse aspects of RNA metabolism, including binding and protecting poly(U) termini of nascent RNA polymerase III transcripts from exonuclease digestion, processing 5' and 3' ends of pre-tRNA precursors, acting as an RNA chaperone, and binding viral RNAs associated with hepatitis C virus. Autoantibodies reacting with this protein are found in the sera of patients with Sjogren syndrome and systemic lupus erythematosus. Alternative promoter usage results in two different transcript variants which encode the same protein.

Applications:

WB

Name of antibody:

SSB

Immunogen:

Fusion protein of human SSB

Full name:

Sjogren syndrome antigen B

Synonyms:

La; LARP3; La/SSB

SwissProt:

P05455

WB Predicted band size:

47 kDa

WB Positive control:

MCF7, A549, Jurkat and Hela cell lysates

WB Recommended dilution:

1000-5000