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  • MCM3AP抗原(重組蛋白)

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    • 品牌 : 通蔚生物
    • 目錄號(hào) : TW17487
    • 應(yīng)用 : 僅供科研使用
    • 保存條件 : 低溫保存
    • 貨期 : 現(xiàn)貨
    • 商品庫存:90
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中文名稱:  MCM3AP抗原(重組蛋白)

英文名稱:MCM3AP Antigen (Recombinant Protein)

別      名: GANP; SAC3; MAP80

儲(chǔ)      存: 冷凍(-20℃)

相關(guān)類別: 抗原

概  述:

Fusion protein corresponding to N terminal 150 amino acids of human MCM3AP


技術(shù)規(guī)格:

Full name:

minichromosome maintenance complex component 3 associated protein

Synonyms:

GANP; SAC3; MAP80

Swissprot:

O60318

Gene Accession:

BC104958

Purity:

>85%, as determined by Coomassie blue stained SDS-PAGE

Expression system:

Escherichia coli

Tags:

His tag C-Terminus, GST tag N-Terminus

Background:

The minichromosome maintenance protein 3 (MCM3) is one of the MCM proteins essential for the initiation of DNA replication. The protein encoded by this gene is a MCM3 binding protein. It was reported to have phosphorylation-dependent DNA-primase activity, which was up-regulated in antigen immunization induced germinal center. This protein was demonstrated to be an acetyltransferase that acetylates MCM3 and plays a role in DNA replication. The mutagenesis of a nuclear localization signal of MCM3 affects the binding of this protein with MCM3, suggesting that this protein may also facilitate MCM3 nuclear localization. This gene is expressed in the brain or in neuronal tissue. An allelic variant encoding amino acid Lys at 915, instead of conserved Glu, has been identified in patients with mild intellectual disability.