兔抗DTX3L多克隆抗體

Background:

The Deltex family is responsible for influencing Notch signaling and may regulate transcription through interactions with specific transcription factors. Deltex proteins have a basic N-terminus, a central proline-rich region and a C-terminal RING-type zinc finger domain, a motif often found in ubiquitin-protein isopeptide ligases (E3). The RING-type zinc finger domain binds two Zn2+ atoms and forms a cross-brace motif that is essential for many proteins involved the ubiquitination pathway. DTX3L (Deltex-3-like), also known as BBAP, is a 740 amino acid protein that is similar to Deltex-3 and acts as a ubiquitin ligase in vitro. DTX3L can heterodimerize with Deltex-1, a transcriptional regulator, thereby enhancing the activity of the E3 ubiquitin ligase complex and increasing the influence of E3 on the Notch signaling pathway.

Applications:

ELISA, WB

Name of antibody:

DTX3L

Immunogen:

Fusion protein of human DTX3L

Full name:

deltex 3 like, E3 ubiquitin ligase

Synonyms:

BBAP

SwissProt:

Q8TDB6

ELISA Recommended dilution:

2000-5000

WB Predicted band size:

84 kDa

WB Positive control:

A431 cell lysate

WB Recommended dilution:

200-1000