兔抗SNCA多克隆抗體

Background:

Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Four alternatively spliced transcripts encoding two different isoforms have been identified for this gene.

Applications:

ELISA, IHC

Name of antibody:

SNCA

Immunogen:

Synthetic peptide of human SNCA

Full name:

synuclein, alpha (non A4 component of amyloid precursor)

Synonyms：

PD1; NACP; PARK1; PARK4

SwissProt:

P37840

ELISA Recommended dilution:

1000-2000

IHC positive control:

Human brain and Human thyroid cancer

IHC Recommend dilution:

25-100