兔抗CDKN2A多克隆抗體

Background:

This gene generates several transcript variants which differ in their first exons. At least three alternatively spliced variants encoding distinct proteins have been reported, two of which encode structurally related isoforms known to function as inhibitors of CDK4 kinase. The remaining transcript includes an alternate first exon located 20 Kb upstream of the remainder of the gene; this transcript contains an alternate open reading frame (ARF) that specifies a protein which is structurally unrelated to the products of the other variants. This ARF product functions as a stabilizer of the tumor suppressor protein p53 as it can interact with, and sequester, the E3 ubiquitin-protein ligase MDM2, a protein responsible for the degradation of p53.

Applications:

ELISA, IHC

Name of antibody:

CDKN2A

Immunogen:

Synthetic peptide of human CDKN2A

Full name:

cyclin-dependent kinase inhibitor 2A

Synonyms:

ARF; MLM; P14; P16; P19; CMM2; INK4; MTS1; TP16; CDK4I; CDKN2; INK4A; MTS-1; P14ARF; P19ARF; P16INK4; P16INK4A; P16-INK4A

SwissProt:

P42771

IHC positive control:

Human gastric cancer and human thyroid cancer

IHC Recommend dilution:

50-200