兔抗KIF3A多克隆抗體

Background:

Kinesin-like protein KIF3A is a protein that in humans is encoded by the KIF3A gene. Members of the heterotrimeric kinesin II family of microtubule associated motors generally contain two different motor subunits from the KIF3 family, which includes KIF3A, B and C. KIF3 isoforms mediate anterograde transport of membrane bound organelles in neurons and melanosomes, transport between the endoplasmic reticulum and the Golgi, and transport of protein complexes within cilia and flagella required for their morphogenesis. KIF3A may influence neurogenesis at the level of embryonic cellular events, where the asymmetry of the genetic control circuit controlling left-right (L-R) axis determination is defined. Loss of KIF3A function in mice photoreceptors causes apoptotic cell death, suggesting that kinesin II mediated transport is required for proper cell fate.

Applications:

ELISA, WB, IHC

Name of antibody:

KIF3A

Immunogen:

Fusion protein of human KIF3A

Full name:

kinesin family member 3A

Synonyms：

FLA10; KLP-20

SwissProt:

Q9Y496

ELISA Recommended dilution:

2000-5000

IHC positive control:

Human thyroid cancer and human lung cancer

IHC Recommend dilution:

25-100

WB Predicted band size:

80 kDa

WB Positive control:

Mouse brain and human fetal brain tissue, human brain malignant glioma tissue

WB Recommended dilution:

200-1000