兔抗CLDN16多克隆抗體

Background:

Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. It is found primarily in the kidneys, specifically in the thick ascending limb of Henle, where it acts as either an intercellular pore or ion concentration sensor to regulate the paracellular resorption of magnesium ions. Defects in this gene are a cause of primary hypomagnesemia, which is characterized by massive renal magnesium wasting with hypomagnesemia and hypercalciuria, resulting in nephrocalcinosis and renal failure. This gene and the CLDN1 gene are clustered on chromosome 3q28.

Applications:

ELISA, IHC

Name of antibody:

CLDN16

Immunogen:

Synthetic peptide of human CLDN16

Full name:

claudin 16

Synonyms:

HOMG3; PCLN1

SwissProt:

Q9Y5I7

ELISA Recommended dilution:

5000-10000

IHC positive control:

Human tonsil and Human brain

IHC Recommend dilution:

25-100