兔抗SHC1多克隆抗體

Background:

This gene encodes three main isoforms that differ in activities and subcellular location. While all three are adapter proteins in signal transduction pathways, the longest (p66Shc) may be involved in regulating life span and the effects of reactive oxygen species. The other two isoforms, p52Shc and p46Shc, link activated receptor tyrosine kinases to the Ras pathway by recruitment of the GRB2/SOS complex. p66Shc is not involved in Ras activation. Unlike the other two isoforms, p46Shc is targeted to the mitochondrial matrix. Several transcript variants encoding different isoforms have been found for this gene.

Applications:

ELISA, WB, IHC

Name of antibody:

SHC1

Immunogen:

Fusion protein of human SHC1

Full name:

SHC adaptor protein 1

Synonyms:

SHC; SHCA

SwissProt:

P29353

ELISA Recommended dilution:

5000-10000

IHC positive control:

Human cervical cancer

IHC Recommend dilution:

25-100

WB Predicted band size:

63 kDa

WB Positive control:

Hela, HepG2, NIH/3T3, 293T, Jurkat, RAW264.7 and 231 cell lysates

WB Recommended dilution:

200-1000