兔抗ARHGEF11多克隆抗體

Background:

Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals. A similar protein in rat interacts with glutamate transporter EAAT4 and modulates its glutamate transport activity. Expression of the rat protein induces the reorganization of the actin cytoskeleton and its overexpression induces the formation of membrane ruffling and filopodia. Two alternative transcripts encoding different isoforms have been described.

Applications:

ELISA, WB, IHC

Name of antibody:

ARHGEF11

Immunogen:

Synthetic peptide of human ARHGEF11

Full name:

Rho guanine nucleotide exchange factor (GEF) 11

Synonyms:

GTRAP48; PDZ-RHOGEF

SwissProt:

O15085

IHC positive control:

Human gastric cancer and human thyroid cancer

IHC Recommend dilution:

25-100

WB Predicted band size:

168 kDa

WB Positive control:

Mouse brain tissue

WB Recommended dilution:

500-2000