兔抗BCAS2多克隆抗體

Background:

BCAS2 (breast carcinoma amplified sequence 2), also designated DAM1 (DNA amplified in mammary carcinoma 1 protein) or spliceosome-associated SPF 27, is a ubiquitously expressed nuclear protein that was originally identified as being overexpressed in various breast cancer cell lines. BCAS2 is now known to be a component of the spliceosome, participating in the removal of introns from mRNA precursors. BCAS2 specifically interacts (in a ligand-independent manner) with TR∫ (thyroid hormone receptor beta), ER (estrogen receptor alpha), ER∫, PR (progesterone receptor), and PPAR (Peroxisome proliferator-activated receptor gamma). BCAS2 functions as an ER coactivator and is capable of enhancing ER-mediated transcription. This suggests that BCAS2 is involved in the development of breast cancer.

Applications:

ELISA, WB, IHC

Name of antibody:

BCAS2

Immunogen:

Fusion protein of human BCAS2

Full name:

breast carcinoma amplified sequence 2

Synonyms：

DAM1; SPF27; Snt309

SwissProt:

O75934

ELISA Recommended dilution:

1000-5000

IHC positive control:

Human colon cancer and Human lung cancer

IHC Recommend dilution:

50-200

WB Predicted band size:

26 kDa

WB Positive control:

A172 and 231 cells

WB Recommended dilution:

200-1000