兔抗SELENOW多克隆抗體

Background:

This gene encodes a selenoprotein containing a selenocysteine (Sec) residue, which is encoded by the UGA codon that normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, the Sec insertion sequence (SECIS) element that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. This protein is highly expressed in skeletal muscle, heart and brain. It belongs to the SelWTH family, which possesses a thioredoxin-like fold and a conserved CxxU (C is cysteine, U is Sec) motif, suggesting a redox function for this gene. Studies in mouse show that this selenoprotein is involved in muscle growth and differentiation, and in the protection of neurons from oxidative stress during neuronal development. A retroprocessed pseudogene of this locus has been identified on chromosome 1. [provided by RefSeq, Aug 2017]

Applications:

ELISA, IHC

Name of antibody:

SELENOW

Immunogen:

Synthetic peptide of human SELENOW

Full name:

selenoprotein W

Synonyms:

selW; SEPW1

SwissProt:

P63302

IHC positive control:

Human colorectal cancer

IHC Recommend dilution:

25-100