兔抗CAPN6多克隆抗體

Background:

Calpains are ubiquitous, well-conserved family of calcium-dependent, cysteine proteases. The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. The large subunit possesses a cysteine protease domain, and both subunits possess calcium-binding domains. Calpains have been implicated in neurodegenerative processes, as their activation can be triggered by calcium influx and oxidative stress. The protein encoded by this gene is highly expressed in the placenta. Its C-terminal region lacks any homology to the calmodulin-like domain of other calpains. The protein lacks critical active site residues and thus is suggested to be proteolytically inactive. The protein may play a role in tumor formation by inhibiting apoptosis and promoting angiogenesis.

Applications:

ELISA, WB

Name of antibody:

CAPN6

Immunogen:

Fusion protein of human CAPN6

Full name:

calpain 6

Synonyms:

CANPX; CAPNX; CalpM; DJ914P14.1

SwissProt:

Q9Y6Q1

ELISA Recommended dilution:

5000-10000

WB Predicted band size:

75 kDa

WB Positive control:

Rat heart tissue, A172 cell, NIH/3T3 cell, TM4 cell lysates

WB Recommended dilution:

500-2000