小鼠抗LIN28A單克隆抗體

Background:

This gene encodes a LIN-28 family RNA-binding protein that acts as a posttranscriptional regulator of genes involved in developmental timing and self-renewal in embryonic stem cells. The encoded protein functions through direct interaction with target mRNAs and by disrupting the maturation of certain miRNAs involved in embryonic development. This protein prevents the terminal processing of the LET7 family of microRNAs which are major regulators of cellular growth and differentiation. Aberrant expression of this gene is associated with cancer progression in multiple tissues.

Applications:

WB

Name of antibody:

LIN28A

Immunogen:

Fusion protein of human LIN28A

Full name:

lin-28 homolog A

Synonyms:

CSDD1; LIN28; LIN-28; ZCCHC1; lin-28A

SwissProt:

Q9H9Z2

WB Predicted band size:

23 kDa

WB Positive control:

NTERA and F9 cell lysates

WB Recommended dilution:

1000-5000