兔抗ACTN1多克隆抗體

Background:

Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, cytoskeletal, alpha actinin isoform and maps to the same site as the structurally similar erythroid beta spectrin gene. Three transcript variants encoding different isoforms have been found for this gene.

Applications:

ELISA, WB

Name of antibody:

ACTN1

Immunogen:

Fusion protein of human ACTN1

Full name:

actinin, alpha 1

Synonyms:

BDPLT15

SwissProt:

P12814

ELISA Recommended dilution:

500-1000

WB Predicted band size:

103/106 kDa

WB Positive control:

231，A549 and Hela cell lysates

WB Recommended dilution:

200-1000