兔抗LMNB1多克隆抗體

Background:

The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. This gene encodes one of the two B type proteins, B1. Alternative splicing results in transcript variants and a duplication of this gene is associated with autosomal dominant adult-onset leukodystrophy (ADLD).

Applications:

ELISA, WB, IHC

Name of antibody:

LMNB1

Immunogen:

Fusion protein of human LMNB1

Full name:

lamin B1

Synonyms：

LMN; ADLD; LMN2; LMNB

SwissProt:

P20700

ELISA Recommended dilution:

2000-10000

IHC positive control:

Human cervical cancer and human thyroid cancer

IHC Recommend dilution:

100-300

WB Predicted band size:

67 kDa

WB Positive control:

Hela and HT-29 cells, human fetal liver tissue and 231 cells, K562 cells and human bladder transitional cells carcinoma tissue

WB Recommended dilution:

1000-5000