兔抗NANOS2多克隆抗體

Background:

Plays a key role in the sexual differentiation of germ cells by promoting the male fate but suppressing the female fate. Represses the female fate pathways by suppressing meiosis, which in turn results in the promotion of the male fate. Maintains the suppression of meiosis by preventing STRA8 expression, which is required for premeiotic DNA replication, after CYP26B1 is decreased. Regulates the localization of the CCR4-NOT deadenylation complex to P-bodies and plays a role in recruiting the complex to trigger the degradation of mRNAs involved in meiosis. Required for the maintenance of the spermatogonial stem cell population. Not essential for the assembly of P-bodies but is required for the maintenance of their normal state (By similarity).

Applications:

ELISA, IHC

Name of antibody:

NANOS2

Immunogen:

Fusion protein of human NANOS2

Full name:

nanos C2HC-type zinc finger 2

Synonyms:

NOS2; ZC2HC12B

SwissProt:

P60321

ELISA Recommended dilution:

2000-5000

IHC positive control:

Human liver cancer and Human breast cancer

IHC Recommend dilution:

50-200