小鼠抗HARS1單克隆抗體

Background:

Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. The protein encoded by this gene is a cytoplasmic enzyme which belongs to the class II family of aminoacyl-tRNA synthetases. The enzyme is responsible for the synthesis of histidyl-transfer RNA, which is essential for the incorporation of histidine into proteins. The gene is located in a head-to-head orientation with HARSL on chromosome five, where the homologous genes share a bidirectional promoter. The gene product is a frequent target of autoantibodies in the human autoimmune disease polymyositis/dermatomyositis. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]

Applications:

WB

Name of antibody:

HARS1

Immunogen:

Fusion protein of human HARS1

Full name:

histidyl-tRNA synthetase 1

Synonyms:

HRS; HARS; CMT2W; USH3B

SwissProt:

P12081

WB Predicted band size:

57 kDa

WB Positive control:

T47D, COS7 and Hela cell lysates

WB Recommended dilution:

1000-5000