購物車
幫助
021-54845833/15800441009
|
Fusion protein corresponding to a region derived from 36-145 amino acids of human GRK4 |
技術(shù)規(guī)格
|
Full name: |
G protein-coupled receptor kinase 4 |
|
Synonyms: |
IT11; GPRK4; GRK4a; GPRK2L |
|
Swissprot: |
P32298 |
|
Gene Accession: |
BC117320 |
|
Purity: |
>85%, as determined by Coomassie blue stained SDS-PAGE |
|
Expression system: |
Escherichia coli |
|
Tags: |
His tag C-Terminus, GST tag N-Terminus |
|
Background: |
This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating its deactivation. This gene has been linked to both genetic and acquired hypertension. Specifically phosphorylates the activated forms of G protein-coupled receptors. GRK4-alpha can phosphorylate rhodopsin and its activity is inhibited by calmodulin; the other three isoforms do not phosphorylate rhodopsin and do not interact with calmodulin. GRK4-alpha and GRK4-gamma phosphorylate DRD3. Phosphorylates ADRB2. |
