小鼠抗PSMA6單克隆抗體

Background:

The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. A pseudogene has been identified on the Y chromosome. [provided by RefSeq].

Applications:

WB, IHC, FC

Name of antibody:

PSMA6

Immunogen:

Fusion protein of human PSMA6

Full name:

proteasome (prosome, macropain) subunit, alpha type, 6 (PSMA6), transcript variant 1

Synonyms:

IOTA; p27K; PROS27

SwissProt:

P60900

IHC positive control:

carcinoma of human lung tissue and adenocarcinoma of human ovary tissue; carcinoma of human bladder tissue and carcinoma of human prostate tissue

IHC Recommend dilution:

30-150

WB Predicted band size:

27 kDa

WB Positive control:

HepG2, Hela, SVT2, A549, COS7, Jurkat, MDCK, PC12, MCF-7 cell lysates

WB Recommended dilution:

500-2000