兔抗GCLC多克隆抗體

Background:

Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase is the first rate-limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunit. This locus encodes the catalytic subunit, while the regulatory subunit is derived from a different gene located on chromosome 1p22-p21. Mutations at this locus have been associated with hemolytic anemia due to deficiency of gamma-glutamylcysteine synthetase and susceptibility to myocardial infarction.

Applications:

ELISA, WB, IHC

Name of antibody:

GCLC

Immunogen:

Fusion protein of human GCLC

Full name:

glutamate-cysteine ligase, catalytic subunit

Synonyms：

GCL; GCS; GLCL; GLCLC

SwissProt:

P48506

ELISA Recommended dilution:

5000-10000

IHC positive control:

Human brain

IHC Recommend dilution:

25-100

WB Predicted band size:

73 kDa

WB Positive control:

Raw264.7，A549，Hepg2 and Jurkat cell

WB Recommended dilution:

500-2000