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  • DPM1抗原(重組蛋白)

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    • 品牌 : 通蔚生物
    • 目錄號 : TW16544
    • 應用 : 僅供科研使用
    • 保存條件 : 低溫保存
    • 貨期 : 現(xiàn)貨
    • 商品庫存:60
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中文名稱: DPM1抗原(重組蛋白)

英文名稱: DPM1 Antigen (Recombinant Protein)

別     名: MPDS; CDGIE

儲     存: 冷凍(-20℃)

相關類別: 抗原

概     述

Full length fusion protein

技術(shù)規(guī)格

Full name:

dolichyl-phosphate mannosyltransferase polypeptide 1, catalytic subunit

Synonyms:

MPDS; CDGIE

Swissprot:

O60762

Gene Accession:

BC008466

Purity:

>85%, as determined by Coomassie blue stained SDS-PAGE

Expression system:

Escherichia coli

Tags:

His tag C-Terminus, GST tag N-Terminus

Background:

Dolichol-phosphate mannose (Dol-P-Man) serves as a donor of mannosyl residues on the lumenal side of the endoplasmic reticulum (ER). Lack of Dol-P-Man results in defective surface expression of GPI-anchored proteins. Dol-P-Man is synthesized from GDP-mannose and dolichol-phosphate on the cytosolic side of the ER by the enzyme dolichyl-phosphate mannosyltransferase. Human DPM1 lacks a carboxy-terminal transmembrane domain and signal sequence and is regulated by DPM2. Mutations in this gene are associated with congenital disorder of glycosylation type Ie. Alternative splicing results in multiple transcript variants.