歡迎來到上海通蔚！

021-54845833/15800441009

品質(zhì)保證 · 通蔚試劑

當(dāng)前位置: 首頁 > 科研產(chǎn)品 > 科研抗體 > 其他抗體 > CDKN2AIP抗原（重組蛋白）

產(chǎn)品中心

  • CDKN2AIP抗原（重組蛋白）

    規(guī)格：
    數(shù)量：

    購買數(shù)量

    價(jià)格：￥
    • 品牌 : 通蔚生物
    • 目錄號(hào) : TW16698
    • 應(yīng)用 : 僅供科研使用
    • 保存條件 : 低溫保存
    • 貨期 : 現(xiàn)貨
    • 商品庫存：40
  • 商品詳情
  • 參考文獻(xiàn)
  • 說明書下載
  • 商品評(píng)論0
  • 相關(guān)產(chǎn)品

中文名稱： CDKN2AIP抗原（重組蛋白）
英文名稱： CDKN2AIP Antigen (Recombinant Protein)
別       名： CARF
儲(chǔ)       存： 冷凍（-20℃）
相關(guān)類別： 抗原

概述

Fusion protein corresponding to a region derived from 175-425 amino acids of human CDKN2AIP

技術(shù)規(guī)格

Full name:

CDKN2A interacting protein

Synonyms:

CARF

Swissprot:

Q9NXV6

Gene Accession:

BC022270

Purity:

>85%, as determined by Coomassie blue stained SDS-PAGE

Expression system:

Escherichia coli

Tags:

His tag C-Terminus, GST tag N-Terminus

Background:

CDKN2AIP (CDKN2A-interacting protein), also known as CARF, is a 580 amino acid protein that activates p53 via p14 ARF (alternate reading frame)-dependent and independent pathways. CDKN2AIP-dependent activation of p53, a protein that up-regulates growth arrest and apoptosis-related genes in response to stress signals, leads to an enhancement of p53 function. Expression levels of CDKN2AIP and p53 show an inverse relationship that is caused by a negative-feedback control via a proteasome-mediated degradation pathway. CDKN2AIP is expressed ubiquitously across tissue samples and, along with p14 ARF, is localized to the perinucleolar region within the nucleus.