中文名稱(chēng): CENPC抗原(重組蛋白)
英文名稱(chēng): CENPC Antigen (Recombinant Protein)
別 名: MIF2; hcp-4; CENP-C; CENPC1
儲(chǔ) 存: 冷凍(-20℃)
相關(guān)類(lèi)別: 抗原
概 述:
Fusion protein corresponding to C terminal 250 amino acids of human CENPC |
Full name: |
centromere protein C |
Synonyms: |
MIF2; hcp-4; CENP-C; CENPC1 |
Swissprot: |
Q03188 |
Gene Accession: |
BC030695 |
Purity: |
>85%, as determined by Coomassie blue stained SDS-PAGE |
Expression system: |
Escherichia coli |
Tags: |
His tag C-Terminus, GST tag N-Terminus |
Background: |
Centromere protein C 1 is a centromere autoantigen and a component of the inner kinetochore plate. The protein is required for maintaining proper kinetochore size and a timely transition to anaphase. A putative pseudogene exists on chromosome 12. Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. |