兔抗ALDOB多克隆抗體

WB Recommended dilution:

500-2000

WB Positive control:

Mouse liver tissue

WB Predicted band size:

39 kDa

IHC Recommend dilution:

50-200

IHC positive control:

Human cervical cancer and Human esophagus cancer

ELISA Recommended dilution:

2000-5000

SwissProt:

P05062

Synonyms：

ALDB; ALDO2

Full name:

Aldolase B, fructose-bisphosphate

Immunogen:

Synthetic peptide of human ALDOB

Name of antibody:

ALDOB

Applications:

ELISA, WB, IHC

Background:

Fructose-1,6-bisphosphate aldolase (EC 4.1.2.13) is a tetrameric glycolytic enzyme that catalyzes the reversible conversion of fructose-1,6-bisphosphate to glyceraldehyde 3-phosphate and dihydroxyacetone phosphate. Vertebrates have 3 aldolase isozymes which are distinguished by their electrophoretic and catalytic properties. Differences indicate that aldolases A, B, and C are distinct proteins, the products of a family of related 'housekeeping' genes exhibiting developmentally regulated expression of the different isozymes. The developing embryo produces aldolase A, which is produced in even greater amounts in adult muscle where it can be as much as 5% of total cellular protein. In adult liver, kidney and intestine, aldolase A expression is repressed and aldolase B is produced. In brain and other nervous tissue, aldolase A and C are expressed about equally. There is a high degree of homology between aldolase A and C. Defects in ALDOB cause hereditary fructose intolerance.