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  • SPATA13抗原(重組蛋白)

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    • 品牌 : 通蔚生物
    • 目錄號 : TW17254
    • 應(yīng)用 : 僅供科研使用
    • 保存條件 : 低溫保存
    • 貨期 : 現(xiàn)貨
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中文名稱: SPATA13抗原(重組蛋白)

英文名稱: SPATA13 Antigen (Recombinant Protein)

別      名: ASEF2; ARHGEF29; RP11-307N16.3

儲      存: 冷凍(-20℃)

相關(guān)類別: 抗原

概述

Fusion protein corresponding to a region derived from 240-424 amino acids of human SPATA13

技術(shù)規(guī)格

Full name:

Spermatogenesis associated 13

Synonyms:

ASEF2; ARHGEF29; RP11-307N16.3

Swissprot:

Q96N96

Gene Accession:

BC109291

Purity:

>85%, as determined by Coomassie blue stained SDS-PAGE

Expression system:

Escherichia coli

Tags:

His tag C-Terminus, GST tag N-Terminus

Background:

Acts as guanine nucleotide exchange factor (GEF) for RHOA, RAC1 and CDC42 GTPases. Regulates cell migration and adhesion assembly and disassembly through a RAC1, PI3K, RHOA and AKT1-dependent mechanism. Increases both RAC1 and CDC42 activity, but decreases the amount of active RHOA. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Involved in tumor angiogenesis and may play a role in intestinal adenoma formation and tumor progression. Both the ABR and the SH3 domains contribute to maintaining the protein in an inhibited conformation by associating with the C-terminal tail. Binding of these domains to the C-terminal tail inhibits the activity of the protein by blocking a region that is required for its GEF activity.