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  • RAF1抗原(重組蛋白)

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    • 品牌 : 通蔚生物
    • 目錄號 : TW17667
    • 應用 : 僅供科研使用
    • 保存條件 : 低溫保存
    • 貨期 : 現(xiàn)貨
    • 商品庫存:75
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中文名稱:RAF1抗原(重組蛋白)

英文名稱: RAF1 Antigen (Recombinant Protein)

儲      存: 冷凍(-20℃)

相關類別: 抗原

概述

Fusion protein corresponding to a region derived from 349-609 amino acids of human RAF1


技術規(guī)格

Full name:

Raf-1 proto-oncogene, serine/threonine kinase

Synonyms:

NS5; CRAF; Raf-1; c-Raf; CMD1NN

Swissprot:

P04049

Gene Accession:

BC018119

Purity:

>85%, as determined by Coomassie blue stained SDS-PAGE

Expression system:

Escherichia coli

Tags:

His tag C-Terminus, GST tag N-Terminus

Background:

This gene is the cellular homolog of viral raf gene (v-raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated, the cellular RAF1 protein can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2, which in turn phosphorylate to activate the serine/threonine specific protein kinases, ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation and cell migration.