兔抗DDR1(Phospho-Tyr513) 多克隆抗體

Background:

Receptor tyrosine kinases play a key role in the communication of cells with their microenvironment. These kinases are involved in the regulation of cell growth, differentiation and metabolism. The protein encoded by this gene belongs to a subfamily of tyrosine kinase receptors with homology to Dictyostelium discoideum protein discoidin I in their extracellular domain, and that are activated by various types of collagen. Expression of this protein is restricted to epithelial cells, particularly in the kidney, lung, gastrointestinal tract, and brain. In addition, it has been shown to be significantly overexpressed in several human tumors. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Feb 2011]

Applications:

WB, IHC

Name of antibody:

DDR1(Phospho-Tyr513)

Immunogen:

Peptide sequence around phosphorylation site of tyrosine 513 (K-K-Y(p)-V-R) derived from Human DDR1 .

Full name:

discoidin domain receptor tyrosine kinase 1

Synonyms：

CAK; DDR; NEP; HGK2; PTK3; RTK6; TRKE; CD167; EDDR1; MCK10; NTRK4; PTK3A

SwissProt:

Q08345

IHC positive control:

Human brain tissue

IHC Recommend dilution:

50-100

WB Predicted band size:

101 kDa

WB Positive control:

Jurkat cells lysates

WB Recommended dilution:

500-1000