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  • IPO4 抗原（重組蛋白）

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    • 品牌 : 通蔚生物
    • 目錄號 : TW17997
    • 應(yīng)用 : 僅供科研使用
    • 保存條件 : 低溫保存
    • 貨期 : 現(xiàn)貨
    • 商品庫存：90
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中文名稱：  IPO4 抗原（重組蛋白）

英文名稱： IPO4 Antigen (Recombinant Protein)

別      名： importin 4; Imp4

儲      存： 冷凍（-20℃）

相關(guān)類別： 抗原

概述

Fusion protein corresponding to C terminal 250amino acids of human IPO4


技術(shù)規(guī)格

Full name:

importin 4

Synonyms:

Imp4

Swissprot:

Q8TEX9

Gene Accession:

BC003690

Purity:

>85%, as determined by Coomassie blue stained SDS-PAGE

Expression system:

Escherichia coli

Tags:

His tag C-Terminus, GST tag N-Terminus

Background:

Importin-4 is a protein that in humans is encoded by the IPO4 gene. Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran.