英文名稱: VAC14 Antigen (Recombinant Protein)
別 名: TRX; TAX1BP2; ArPIKfyve
儲 存: 冷凍(-20℃)
相關(guān)類別: 抗原
概 述:
Fusion protein corresponding to a region derived from 583-782 amino acids of human VAC14 |
Full name: |
VAC14 component of PIKFYVE complex |
Synonyms: |
TRX; TAX1BP2; ArPIKfyve |
Swissprot: |
Q08AM6 |
Gene Accession: |
BC007214 |
Purity: |
>85%, as determined by Coomassie blue stained SDS-PAGE |
Expression system: |
Escherichia coli |
Tags: |
His tag C-Terminus, GST tag N-Terminus |
Background: |
This gene encodes a scaffold protein that is a component of the PIKfyve protein kinase complex. This complex is responsible for the synthesis of phosphatidylinositol 3,5-bisphosphate, an important component of cellular membranes, from phosphatidylinositol 3-phosphate. Mice lacking a functional copy of this gene exhibit severe neurodegeneration. Mutations in the human gene have been identified in patients with a childhood onset progressive neurological disorder characterized by impaired movement, dystonia, and striatal abnormalities. |