歡迎來(lái)到上海通蔚!

021-54845833/15800441009

品質(zhì)保證 · 通蔚試劑

當(dāng)前位置: 首頁(yè) > 科研產(chǎn)品 > 科研抗體 > 其他抗體 > HLA-DQB1 抗原(重組蛋白)

產(chǎn)品中心

  • HLA-DQB1 抗原(重組蛋白)

    規(guī)格:
    數(shù)量:

    購(gòu)買(mǎi)數(shù)量

    價(jià)格:
    • 品牌 : 通蔚生物
    • 目錄號(hào) : TW18730
    • 應(yīng)用 : 僅供科研使用
    • 保存條件 : 低溫保存
    • 貨期 : 現(xiàn)貨
    • 商品庫(kù)存:90
  • 商品詳情
  • 參考文獻(xiàn)
  • 說(shuō)明書(shū)下載
  • 商品評(píng)論0
  • 相關(guān)產(chǎn)品

中文名稱(chēng):HLA-DQB1 抗原(重組蛋白)

英文名稱(chēng): HLA-DQB1 Antigen (Recombinant Protein)

別      名: major histocompatibility complex, class II, DQ beta 1; IDDM1; CELIAC1; HLA-DQB

儲(chǔ)      存: 冷凍(-20℃)

相關(guān)類(lèi)別: 抗原

概     述:

Fusion protein corresponding to a region derived from 33-261 amino acids of human HLA-DQB1


技術(shù)規(guī)格:

Full name:

major histocompatibility complex, class II, DQ beta 1

Synonyms:

IDDM1; CELIAC1; HLA-DQB

Swissprot:

P01920

Gene Accession:

BC012106

Purity:

>85%, as determined by Coomassie blue stained SDS-PAGE

Expression system:

Escherichia coli

Tags:

His tag C-Terminus, GST tag N-Terminus

Background:

HLA-DQB1 belongs to the HLA class II beta chain paralogs. This class II molecule is a heterodimer consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and it contains six exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DQ molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to four different molecules. Typing for these polymorphisms is routinely done for bone marrow transplantation. Alternative splicing results in multiple transcript variants.