兔抗DZIP1多克隆抗體

Background:

DZIP1(DAZ interacting protein 1) is also known as DZIP or DZIP2 and is a 867 amino acid protein which is expressed as 3 isoforms, designated DZIPb, DZIPt1 and DZIPt2. DZIP1 is localized to testis, oocytes, ovary and fetal brain, as well as in embryonic stem cells and germ cells. In testis, DZIP1 is localized to the nucleus and also shows some cytoplasmic distribution in spermatogonia. DZIP1 belongs to the C2H2-type zinc-finger protein family, and, characteristc of the C2H2-type zinc-finger protein family, DZIP1 contains one C2H2-type zinc-finger region through which it is thought to interact with DAZ, an interaction that promotes spermiogenesis. DZIP1 expression is not found in those afflicted with Sertoli cell-only syndrome (characterized by the absence of germ cells in the testis), suggesting that the lack of DZIP1 may be involved in the pathogenesis of Sertoli cell-only syndrome-induced male sterility

Applications:

ELISA, IHC

Name of antibody:

DZIP1

Immunogen:

Synthetic peptide of human DZIP1

Full name:

DAZ interacting zinc finger protein 1

Synonyms:

DZIP; DZIPt1

SwissProt:

Q86YF9

ELISA Recommended dilution:

5000-10000

IHC positive control:

Human liver cancer;

IHC Recommend dilution:

25-100