兔抗UBE2D1多克隆抗體

Background:

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is closely related to a stimulator of iron transport (SFT), and is up-regulated in hereditary hemochromatosis. It also functions in the ubiquitination of the tumor-suppressor protein p53 and the hypoxia-inducible transcription factor HIF1alpha by interacting with the E1 ubiquitin-activating enzyme and the E3 ubiquitin-protein ligases. Two transcript variants encoding different isoforms have been found for this gene.

Applications:

ELISA, WB, IHC

Name of antibody:

UBE2D1

Immunogen:

Fusion protein of human UBE2D1

Full name:

ubiquitin conjugating enzyme E2 D1

Synonyms:

SFT; UBCH5; UBC4/5; UBCH5A; E2(17)KB1

SwissProt:

P51668

ELISA Recommended dilution:

5000-10000

IHC positive control:

Human liver cancer

IHC Recommend dilution:

200-400

WB Predicted band size:

17 kDa

WB Positive control:

Jurkat, 231 and LOVO cell lysates

WB Recommended dilution:

1000-5000