中文名稱: UBXN1 抗原(重組蛋白)
英文名稱: UBXN1 Antigen (Recombinant Protein)
別 名: UBX domain protein 1; 2B28; SAKS1; UBXD10
儲 存: 冷凍(-20℃)
相關(guān)類別: 抗原
概 述
Full name: |
UBX domain protein 1 |
Synonyms: |
2B28; SAKS1; UBXD10 |
Swissprot: |
Q04323 |
Gene Accession: |
BC001372 |
Purity: |
>85%, as determined by Coomassie blue stained SDS-PAGE |
Expression system: |
Escherichia coli |
Tags: |
His tag C-Terminus, GST tag N-Terminus |
Background: |
Ubiquitin-binding protein that interacts with the BRCA1-BARD1 heterodimer, and regulates its activity. Specifically binds 'Lys-6'-linked polyubiquitin chains. Interaction with autoubiquitinated BRCA1, leads to inhibit the E3 ubiquitin-protein ligase activity of the BRCA1-BARD1 heterodimer. Component of a complex required to couple deglycosylation and proteasome-mediated degradation of misfolded proteins in the endoplasmic reticulum that are retrotranslocated in the cytosol. |