兔抗PSMC2多克隆抗體

Background:

The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity.

Applications:

ELISA, WB, IHC

Name of antibody:

PSMC2

Immunogen:

Fusion protein of human PSMC2

Full name:

proteasome (prosome, macropain) 26S subunit, ATPase, 2

Synonyms：

S7; MSS1; Nbla10058

SwissProt:

P35998

ELISA Recommended dilution:

2000-5000

IHC positive control:

Human thyroid cancer and human breast cancer

IHC Recommend dilution:

50-200

WB Predicted band size:

49 kDa

WB Positive control:

231 cells

WB Recommended dilution:

500-2000