兔抗SP1 (Phospho-Thr739)多克隆抗體

Background:

Transcription factor that can activate or repress transcription in response to physiological and pathological stimuli. Binds with high affinity to GC-rich motifs and regulates the expression of a large number of genes involved in a variety of processes such as cell growth, apoptosis, differentiation and immune responses. Highly regulated by post-translational modifications (phosphorylations, sumoylation, proteolytic cleavage, glycosylation and acetylation). Binds also the PDGFR-alpha G-box promoter. May have a role in modulating the cellular response to DNA damage. Implicated in chromatin remodeling. Plays a role in the recruitment of SMARCA4/BRG1 on the c-FOS promoter. Plays an essential role in the regulation of FE65 gene expression.

Applications:

WB

Name of antibody:

SP1 (Phospho-Thr739)

Immunogen:

Synthetic peptide of human SP1 (Phospho-Thr739)

Full name:

Sp1 transcription factor (Phospho-Thr739)

SwissProt:

P08047

WB Predicted band size:

81 kDa

WB Positive control:

NIH/3T3 cells treated with serum starvation

WB Recommended dilution:

500-1000