兔抗ASCC1多克隆抗體

Background:

This gene encodes a subunit of the activating signal cointegrator 1 (ASC-1) complex. The ASC-1 complex is a transcriptional coactivator that plays an important role in gene transactivation by multiple transcription factors including activating protein 1 (AP-1), nuclear factor kappa-B (NF-kB) and serum response factor (SRF). The encoded protein contains an N-terminal KH-type RNA-binding motif which is required for AP-1 transactivation by the ASC-1 complex. Mutations in this gene are associated with Barrett esophagus and esophageal adenocarcinoma. Alternatively spliced transcripts encoding multiple isoforms have been observed for this gene.

Applications:

ELISA, IHC

Name of antibody:

ASCC1

Immunogen:

Fusion protein of human ASCC1

Full name:

activating signal cointegrator 1 complex subunit 1

Synonyms：

p50; CGI-18; ASC1p50

SwissProt:

Q8N9N2

ELISA Recommended dilution:

2000-5000

IHC positive control:

Human thyroid cancer and human esophagus cancer

IHC Recommend dilution:

25-100