兔抗CDKN1C多克隆抗體

Background:

This gene is imprinted, with preferential expression of the maternal allele. The encoded protein is a tight-binding, strong inhibitor of several G1 cyclin/Cdk complexes and a negative regulator of cell proliferation. Mutations in this gene are implicated in sporadic cancers and Beckwith-Wiedemann syndorome, suggesting that this gene is a tumor suppressor candidate. Three transcript variants encoding two different isoforms have been found for this gene.

Applications:

ELISA, IHC

Name of antibody:

CDKN1C

Immunogen:

Synthetic peptide of human CDKN1C

Full name:

cyclin-dependent kinase inhibitor 1C (p57, Kip2)

Synonyms:

BWS, WBS, p57, BWCR, KIP2, IMAGE

SwissProt:

P49918

IHC positive control:

Human gastric cancer and human thyroid cancer

IHC Recommend dilution:

25-100