兔抗BRCA2(Phospho-Ser3291)多克隆抗體

Background:

Inherited mutations in BRCA1 and this gene, BRCA2, confer increased lifetime risk of developing breast or ovarian cancer. Both BRCA1 and BRCA2 are involved in maintenance of genome stability, specifically the homologous recombination pathway for double-strand DNA repair. The BRCA2 protein contains several copies of a 70 aa motif called the BRC motif, and these motifs mediate binding to the RAD51 recombinase which functions in DNA repair. BRCA2 is considered a tumor suppressor gene, as tumors with BRCA2 mutations generally exhibit loss of heterozygosity (LOH) of the wild-type allele. [provided by RefSeq, Dec 2008]

Applications:

WB

Name of antibody:

BRCA2(Phospho-Ser3291)

Immunogen:

Peptide sequence around phosphorylation site of Serine 3291 (F-V-S(p)-P-A) derived from Human BRCA2.

Full name:

breast cancer 2, early onset

Synonyms：

FAD; FACD; FAD1; GLM3; BRCC2; FANCD; PNCA2; FANCD1; BROVCA2

SwissProt:

P51587

WB Predicted band size:

384 kDa

WB Positive control:

293 cells lysates

WB Recommended dilution:

500-1000