兔抗CASP4多克隆抗體

Background:

This gene encodes a protein that is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain and a large and small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This caspase is able to cleave and activate its own precursor protein, as well as caspase 1 precursor. When overexpressed, this gene induces cell apoptosis. Alternative splicing results in transcript variants encoding distinct isoforms.

Applications:

ELISA, IHC

Name of antibody:

CASP4

Immunogen:

Synthetic peptide of human CASP4

Full name:

caspase 4

Synonyms:

TX; Mih1; ICH-2; Mih1/TX; ICEREL-II; ICE(rel)II

SwissProt:

P49662

ELISA Recommended dilution:

5000-10000

IHC positive control:

Human liver cancer and human cervical cancer

IHC Recommend dilution:

30-150