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  • RNF144B 抗原（重組蛋白）

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    • 品牌 : 通蔚生物
    • 目錄號(hào) : TW4637
    • 應(yīng)用 : 僅供科研使用
    • 保存條件 : 低溫保存
    • 貨期 : 現(xiàn)貨
    • 商品庫(kù)存：20
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中文名稱： RNF144B 抗原（重組蛋白）

英文名稱： RNF144B Antigen (Recombinant Protein)

別     名： ring finger protein 144B; PIR2; IBRDC2; p53RFP; bA528A10.3

儲(chǔ)     存： 冷凍（-20℃）

相關(guān)類別： 抗原

概     述

Fusion protein corresponding to N terminal 250 amino acids of human RNF144B

技術(shù)規(guī)格

Full name:

ring finger protein 144B

Synonyms:

PIR2; IBRDC2; p53RFP; bA528A10.3

Swissprot:

Q7Z419

Gene Accession:

BC063311

Purity:

>85%, as determined by Coomassie blue stained SDS-PAGE

Expression system:

Escherichia coli

Tags:

His tag C-Terminus, GST tag N-Terminus

Background:

p53 is the most commonly mutated gene in human cancer identified to date. Expression of p53 leads to inhibition of cell growth by preventing progression of cells from G1 to S phase of the cell cycle. Most importantly, p53 functions to cause arrest of cells in the G1 phase of the cell cycle following any exposure of cells to DNA-damaging agents. The MDM2 (murine double minute-2) protein was initially identified as an oncogene in a murine transformation system. MDM2 functions to bind p53 and block p53-mediated transactivation of cotransfected reporter constructs. The MDM2 gene is amplified in a high percentage of human sarcomas that retain wildtype p53 and tumor cells that overexpress MDM2 can tolerate high levels of p53 expression. Another p53 target protein is the p53-inducible RING finger protein (p53RFP), an auto-ubiquitinylated protein acting as an E3 ubiquitin ligase. p53RFP, also designated IBRDC2 in mouse and rat, receives ubiquitin from specific E2 ubiquitin-conjugating enzymes and transfers it to substrates that promote their degradation by the proteasome. p53RFP may mediate re-entry into the cell cycle.