兔抗CCNC(Ab-275)多克隆抗體

Background:

Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Binds to and activates cyclin-dependent kinase CDK8 that phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex.

Applications:

WB

Name of antibody:

CCNC(Ab-275)

Immunogen:

Synthesized non-phosphopeptide derived from human Cyclin C around the phosphorylation site of serine 275 (N-G-S(p)-Q-N).

Full name:

cyclin C

Synonyms：

CycC

SwissProt:

P24863

WB Predicted band size:

33 kDa

WB Positive control:

LOVO cells lysate

WB Recommended dilution:

500-3000