兔抗CCP110多克隆抗體

Background:

Necessary for centrosome duplication at different stages of procentriole formation. Acts as a key negative regulator of ciliogenesis in collaboration with CEP97 by capping the mother centriole thereby preventing cilia formation (PubMed:17719545 PubMed:17681131, PubMed:23486064). Also involved in promoting ciliogenesis. May play a role in the assembly of the mother centriole subdistal appendages (SDA) thereby effecting the fusion of recycling endosomes to basal bodies during cilia formation (By similarity). Required for correct spindle formation and has a role in regulating cytokinesis and genome stability via cooperation with CALM1 and CETN2 (PubMed:16760425).

Applications:

ELISA, IHC

Name of antibody:

CCP110

Immunogen:

Synthetic peptide corresponding to a region derived from 578-591 amino acids of human CCP110

Full name:

centriolar coiled-coil protein 110

Synonyms:

CP110; Cep110

SwissProt:

O43303

ELISA Recommended dilution:

5000-10000

IHC Positive control:

Human brain;

IHC Recommended dilution:

10-50