兔抗CD40多克隆抗體

Background:

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been found to be essential in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis.

Applications:

ELISA, IHC

Name of antibody:

CD40

Immunogen:

Synthetic peptide of human CD40

Full name:

CD40 molecule, TNF receptor superfamily member 5

Synonyms：

p50; Bp50; CDW40; TNFRSF5

SwissProt:

P25942

ELISA Recommended dilution:

2000-10000

IHC positive control:

Human liver cancer and Human gastric cancer

IHC Recommend dilution:

100-300