兔抗CDC20B多克隆抗體

Background:

WD-repeats are motifs that are found in a variety of proteins and are characterized by a conserved core of 40-60 amino acids that commonly form a tertiary propeller structure. While proteins that contain WD-repeats participate in a wide range of cellular functions, they are generally involved in regulatory mechanisms concerning chromatin assembly, cell cycle control, signal transduction, RNA processing, apoptosis and vesicular trafficking. Cdc20B (cell division cycle 20 homolog B) is a 519 amino acid protein that contains seven WD repeats and is thought to play a role in cell cycle control. Multiple isoforms of Cdc20B exist due to alternative splicing events. The gene encoding Cdc20B maps to human chromosome 5, which contains 181 million base pairs and comprises nearly 6% of the human genome. Deletion of the p arm of chromosome 5 leads to Cri du chat syndrome, while deletion of the q arm or of chromosome 5 altogether is common in therapy-related acute myelogenous leukemias and myelodysplastic syndrome.

Applications:

ELISA, IHC

Name of antibody:

CDC20B

Immunogen:

Synthetic peptide of human CDC20B

Full name:

cell division cycle 20B

Synonyms:

G6VTS76519

SwissProt:

Q86Y33

ELISA Recommended dilution:

5000-10000

IHC positive control:

Human liver cancer

IHC Recommend dilution:

30-150