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  • TFEB 抗原（重組蛋白）

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    • 品牌 : 通蔚生物
    • 目錄號(hào) : TW5411
    • 應(yīng)用 : 僅供科研使用
    • 保存條件 : 低溫保存
    • 貨期 : 現(xiàn)貨
    • 商品庫(kù)存：20
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中文名稱：TFEB 抗原（重組蛋白）

英文名稱：TFEB Antigen (Recombinant Protein)

別      名： transcription factor EB; TCFEB; BHLHE35; ALPHATFEB

儲(chǔ)      存： 冷凍（-20℃）

相關(guān)類別：抗原

概     述

Fusion protein corresponding to a region derived from 300-476 amino acids of human TFEB

技術(shù)規(guī)格

Full name:

transcription factor EB

Synonyms:

TCFEB; BHLHE35; ALPHATFEB

Swissprot:

P19484

Gene Accession:

BC032448

Purity:

>85%, as determined by Coomassie blue stained SDS-PAGE

Expression system:

Escherichia coli

Tags:

His tag C-Terminus, GST tag N-Terminus

Background:

Transcription factor that specifically recognizes and binds E-box sequences (5'-CANNTG-3'). Efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFE3 or MITF. In association with TFE3, activates the expression of CD40L in T-cells, thereby playing a role in T-cell-dependent antibody responses in activated CD4+ T-cells and thymus-dependent humoral immunity. Specifically recognizes and binds the CLEAR-box sequence (5'-GTCACGTGAC-3') present in the regulatory region of many lysosomal genes, leading to activate their expression. It thereby plays a central role in expression of lysosomal genes. Acts as a positive regulator of autophagy by promoting expression of genes involved in autophagy. Specifically recognizes the gamma-E3 box, a subset of E-boxes, present in the heavy-chain immunoglobulin enhancer. Plays a role in the signal transduction processes required for normal vascularization of the placenta. Regulates lysosomal positioning in response to nutrient deprivation by promoting the expression of PIP4P1.